The Safe American Food Exports Act of 2025 (SAFE Act of 2025) seeks to improve the prevention of animal disease spread and protect U.S. agricultural exports. It amends the Animal Health Protection Act to specifically authorize the Secretary of Agriculture to engage with international export markets. This engagement involves negotiating agreements like regionalization , zoning , and compartmentalization with countries that import U.S. livestock and animal products. The primary objective is to lessen the economic impact of animal disease outbreaks on these crucial American exports. These negotiations are intended to incorporate accepted global research advances, without restricting the United States Trade Representative's general trade agreement authority.