The Safe American Food Exports Act of 2025, or SAFE Act of 2025, seeks to enhance the prevention of animal disease spread by amending the Animal Health Protection Act. Its primary goal is to reduce the impact of animal disease outbreaks on United States exports of livestock and animal products. The bill authorizes the Secretary of Agriculture, acting through the Animal and Plant Health Inspection Service, the Under Secretary for Trade, and the Food Safety and Inspection Service, to engage in advance negotiations with governments of countries that are key export markets. These negotiations, conducted in consultation with the U.S. Trade Representative, would establish agreements on measures such as regionalization, zoning, and compartmentalization . Such agreements would address known animal disease threats of trade significance, incorporating accepted global research advances. A rule of construction clarifies that this authority does not limit the U.S. Trade Representative's ability to negotiate other trade agreements or require conditioning them on these animal disease provisions.