This resolution officially designates February 27, 2025, as "Rare Disease Day" to highlight the significant challenges and impact of rare diseases on the United States population. A rare disease is defined as affecting fewer than 200,000 individuals, yet over 30 million Americans are living with one of more than 10,000 known rare conditions. Despite landmark legislation like the Orphan Drug Act and ongoing FDA programs, approximately 95 percent of rare diseases still do not have an FDA-approved treatment. Patients frequently encounter difficulties in securing accurate diagnoses, locating specialized medical expertise, and affording necessary life-altering treatments. By designating this day, the Senate aims to improve public awareness, encourage accurate and early diagnosis, and support national and global research efforts. These initiatives are crucial for accelerating the development of effective treatments, diagnostics, and cures for these often serious and life-threatening conditions.