The Web of Biological Data Act of 2026 mandates the Secretary of Energy to establish a centralized data resource, to be known as the "Web of Biological Data" , through a competitively selected National Laboratory. This Web aims to facilitate biological research by providing a single point of entry for researchers to access various biological datasets, especially those funded by the Federal Government. It is designed to enable advanced computational methods, including artificial intelligence , by ensuring data quality, interoperability, and robust cybersecurity safeguards. The bill outlines a phased implementation, with an initial version (Phase I) to be tested within two years, focusing on specific biological data subtypes and user experience. Within five years, the Web is to be expanded (Phase II) to accommodate diverse biological data, be accessible to U.S. researchers, and include bioinformatic tools for optimized analysis. The Director of the selected National Laboratory is tasked with collaborating with various federal agencies, academia, and industry partners to optimize the Web's usability and performance, and to integrate federally funded data. An advisory board , chaired by the Director and comprising representatives from industry, academia, National Laboratories, and federal agencies, will oversee the Web's implementation. The Director is also required to submit annual reports to Congress detailing progress, cybersecurity vulnerabilities, and future plans. The Act authorizes substantial appropriations, including $30 million for a research and development program, $310 million for Phase I, and $80 million annually for subsequent years, to ensure the successful establishment and expansion of this critical biological data infrastructure.