This legislation mandates the Secretary of Energy to establish a centralized data resource called the "Web of Biological Data" within a National Laboratory. This Web aims to facilitate biological research by enabling advanced computational methods, such as artificial intelligence, through a single point of entry for various biological datasets, especially those funded by the Federal Government. It will include metrics for data quality, such as usability and interoperability, and implement tiered cybersecurity safeguards and access controls to protect sensitive information. The Director of the selected National Laboratory will be responsible for entering into data sharing and cost-sharing agreements, fostering partnerships with academia, industry, and international allies, and establishing a research and development program for biological data science. An implementation plan is required within one year, detailing data acquisition, digitization of samples, and cybersecurity measures. The bill outlines a two-phase approach: Phase I within two years will launch an initial version focusing on specific data types with human-centered design and security, including restrictions on data sharing with adversarial countries. Phase II, within five years, will expand the Web to be fully accessible to U.S. researchers, accommodate diverse biological data, and integrate bioinformatic tools, ensuring data is formatted for training artificial intelligence models . An advisory board , chaired by the Director and comprising representatives from industry, academia, National Laboratories, and federal agencies, will oversee the Web's implementation. The Director must also collaborate with various federal entities, including the National Institute of Standards and Technology and the National Library of Medicine, to ensure data formatting, interoperability, and cybersecurity. The bill authorizes significant appropriations, including $30 million for the research and development program and $310 million for Phase I, with annual reports detailing progress, cybersecurity vulnerabilities, and future plans.