The Securing Enhanced Programs, Systems, and Initiatives for Sepsis Act (SEPSIS Act) aims to significantly reduce sepsis rates across the United States, addressing the critical need for increased federal investment in research, improved data collection, and enhanced support for the infectious disease workforce. Congress finds that sepsis affects 1.7 million individuals annually, causes 350,000 deaths, and is one of the most expensive conditions to treat, with most cases originating outside hospitals and many fatalities being preventable with early recognition and treatment. The bill mandates the Secretary of Health and Human Services, acting through the Director of the Centers for Disease Control and Prevention (CDC), to maintain a dedicated sepsis team. This team is responsible for several key activities, including: Leading an education campaign on best practices for addressing sepsis in hospitals. Improving data collection on pediatric sepsis. Sharing information with the Centers for Medicare & Medicaid Services to inform the development and implementation of sepsis quality measures. Updating sepsis data elements for interoperability. Facilitating efforts across the Department of Health and Human Services to develop outcome measures for sepsis. The Director must submit a report within one year on the development and implementation of sepsis outcome measures for both adult and pediatric populations, considering social and clinical factors. Additionally, annual briefings to Congress are required to cover aggregate data on hospital adoption of sepsis best practices, pediatric sepsis rates, coordination of HHS sepsis efforts, and evaluations of the impact of CDC's Hospital Sepsis Program Core Elements. The legislation also authorizes the Secretary to establish a voluntary Honor Roll Program to recognize hospitals that maintain effective sepsis programs or demonstrate improvements in early detection, effective treatment, and overall reduction of the sepsis burden. To fund these programs, the bill authorizes appropriations of $20,000,000 for each of fiscal years 2026 through 2030.