This bill, known as the SEPSIS Act, aims to significantly reduce sepsis rates across the United States by establishing comprehensive federal programs. It acknowledges that sepsis affects 1.7 million individuals annually, causes 350,000 deaths, and is one of the most expensive conditions to treat, with many cases preventable through early recognition and treatment. The legislation emphasizes the need for increased federal investment in research, workforce support, and the study of successful protocols. The legislation amends the Public Health Service Act, directing the Secretary, through the Centers for Disease Control and Prevention (CDC) Director, to maintain a dedicated sepsis team. This team is mandated to lead education campaigns on best practices, improve data collection on pediatric sepsis, and share information with the Centers for Medicare & Medicaid Services to inform quality measures. It will also update sepsis data elements for interoperability and facilitate efforts across the Department of Health and Human Services to develop robust outcome measures. The bill requires the CDC Director to submit a report within one year on the development of outcome measures for both adult and pediatric populations, considering social and clinical factors. Furthermore, annual briefings to Congress are mandated, covering the adoption of hospital sepsis best practices, pediatric sepsis rates, inter-agency coordination, and evaluations of the impact of core elements on patient care. Finally, the bill authorizes a voluntary Honor Roll Program to recognize hospitals for effective sepsis programs or improvements in early detection, treatment, and overall reduction of the sepsis burden, with an appropriation of $20,000,000 for each of fiscal years 2026 through 2030 to fund these initiatives.