The "American Innovation Act" proposes a substantial and sustained increase in federal funding for basic science research across several key agencies. Beginning in fiscal year 2026 and extending through 2035, the bill authorizes and directly appropriates specific, escalating amounts for these critical scientific endeavors. After 2035, funding levels are set to increase annually based on the Consumer Price Index, ensuring long-term investment. This legislation targets five major federal entities responsible for scientific advancement. These include the National Science Foundation , the Department of Energy's Office of Science , and Department of Defense science and technology programs . Additionally, the National Institute of Standards and Technology's scientific and technical research and services and the National Aeronautics and Space Administration's Science Mission Directorate are slated to receive significant appropriations. A crucial aspect of the bill is its provision to protect these vital research investments. It explicitly exempts the authorized appropriations from budget sequestration under the Balanced Budget and Emergency Deficit Control Act. Furthermore, the budgetary effects of this section are not to be entered on either Statutory PAYGO or Senate PAYGO scorecards, aiming to insulate this funding from future budget constraints and ensure its availability until expended.