This legislation, titled the "Securing Innovation and Research from Adversaries Act," prohibits the use of federal funds for research collaborations with certain foreign entities or individuals. Specifically, any individual or entity receiving a federally funded research award is barred from entering into or supporting research collaborations with entities listed on U.S. government restricted entity lists , or with individuals associated with such entities. The bill broadly defines "research collaboration" to include joint projects, co-authorship, data sharing, personnel exchanges, and other related activities. To ensure consistent implementation, the Director of the Office of Science and Technology Policy, in consultation with relevant agencies, is mandated to issue government-wide guidance. Federal agencies retain the authority to waive this prohibition on a case-by-case basis if it is deemed necessary to advance U.S. national security interests , or if the collaboration is essential for a scientific, public health, or national security purpose that cannot be reasonably achieved otherwise. Any agency granting a waiver must submit a detailed report to Congress within 30 days, outlining the justification and any mitigation measures taken.