This legislation amends the 21st Century Cures Act to clarify the permissible uses of certain federal grants. Specifically, it allows State and Tribal response grants for opioid use disorders to be utilized for activities related to public access opioid overdose reversal kits . The amendment specifies that these grants can cover the acquisition, availability, and maintenance of such kits. Furthermore, the bill provides a clear definition for a "public access opioid overdose reversal kit," stating it must include both opioid overdose reversal medication and comprehensive instructions on how to administer it.