This bill establishes a comprehensive prohibition on federal involvement in research utilizing human fetal tissue derived from induced abortions. Specifically, it forbids any federal department, agency, or office from conducting, funding, approving, or otherwise supporting such research. Furthermore, it prohibits the solicitation or knowing acquisition, receipt, or acceptance of donations of human fetal tissue if it was obtained through an induced abortion or if the pregnancy was initiated solely to provide such tissue. The legislation clarifies that federal entities are still permitted to develop or support the development of new, high-efficiency cell lines, provided these are not derived from human fetal tissue obtained via induced abortion. It also explicitly allows and regulates federal research on human fetal tissue obtained after a miscarriage or stillbirth , amending existing Public Health Service Act provisions to reflect this distinction. These amendments redefine "human fetal tissue" and restrict federal research programs to tissue from miscarriages or stillbirths, while repealing conflicting prior legislation.