Combating Global Corruption Act of 2021 This bill requires the Department of State to develop a program to combat corruption in foreign countries. The State Department must annually report to Congress a tiered list of all foreign countries. The first tier shall contain countries that meet minimum standards for combating public corruption, while the second tier shall contain countries that do not yet meet these standards but are making significant efforts to do so. Third-tier countries do not meet the minimum anti-corruption standards and are not making significant efforts to do so. Factors for assessing efforts to address corruption include a country's compliance with specified relevant international agreements. The State Department must report on whether, for purposes of potential sanctions, foreign persons are engaged in significant corruption in third-tier countries or in relation to the planning, construction, or operation of the Nord Stream 2 pipeline. The State Department must also designate an anti-corruption point of contact in the U.S. diplomatic post in each second- or third-tier country and where the State Department determines that such a point of contact is necessary. The point of contact shall be responsible for enhancing coordination and promoting the implementation of a whole-of-government approach to enhancing the ability of foreign countries to combat public corruption.