The "Joint Task Force to Counter Illicit Synthetic Narcotics Act of 2025" establishes a new interagency body, the Joint Task Force to Counter Illicit Synthetic Narcotics (JTF-ISN) , to address the ongoing substance abuse crisis in the United States. Congress finds that while many government entities combat the opioid epidemic, there is a critical lack of a central entity to coordinate efforts and share information effectively. The JTF-ISN aims to fill this gap by providing strategic coordination and directing counter-opioid and synthetic narcotics activities. The JTF-ISN will comprise representatives from numerous federal departments and agencies, including the Department of Justice (DEA, FBI), Department of the Treasury (FinCEN, OFAC), and the Department of Homeland Security (HSI, CBP, ICE), among others. It will be led by a Director, appointed by the President with Senate confirmation, who will report to the Attorney General and provide regular reports to Congress on the Task Force's plans, budget, and operational achievements. These reports will specifically detail efforts to investigate and prosecute trafficking crimes, including those related to the People's Republic of China's involvement in the opioid crisis. The primary mission of the JTF-ISN is to investigate and prosecute violations of federal law related to the trafficking of illicit synthetic narcotics, including associated financial crimes. Its authorities include facilitating information sharing, developing strategies to address China's role, and conducting direct operational activities such as joint operations and raids to disrupt trafficking networks. Importantly, the bill clarifies that the JTF-ISN's focus is on suppliers and networks, explicitly stating it cannot investigate or prosecute individuals for personal drug use or low-level dealing not connected to larger trafficking organizations.