The "End Tobacco Loopholes Act" seeks to establish tax rate parity among all tobacco products by substantially increasing federal excise taxes. It raises taxes on traditional cigarettes, roll-your-own tobacco, and pipe tobacco to align them with higher rates. The bill also significantly increases taxes on various forms of smokeless tobacco, including a new category for discrete single-use units , and on both small and large cigars. A key provision introduces a new federal excise tax on taxable nicotine , specifically targeting nicotine that has been extracted, concentrated, or synthesized for use in vaping products. This tax applies unless the nicotine is part of a product approved by the Food and Drug Administration for medical use. The legislation also includes provisions for annual inflation adjustments to all tobacco tax rates and imposes floor stocks taxes on products held for sale when new rates take effect, ensuring revenue protection and a smooth transition for the new tax structure.