The HIDTA Enhancement Act amends the Office of National Drug Control Policy Reauthorization Act of 1998 to strengthen efforts against fentanyl trafficking. It requires High Intensity Drug Trafficking Areas (HIDTAs) to submit detailed reports on their use of funds to investigate and prosecute organizations and individuals involved in fentanyl and fentanyl-related substance trafficking. These reports must include the amounts of fentanyl seized and provide law enforcement and predictive data on patterns and trends in substance abuse, trafficking, and transportation of these dangerous substances. The bill significantly increases the annual authorization for the HIDTA program to $333,000,000 for fiscal years 2025 through 2030, expanding the purposes for which these funds can be used to include fentanyl prevention, seizure, and interdiction activities. Furthermore, it mandates the Attorney General to make available sufficient investigative and prosecutorial resources, including the temporary reassignment of Assistant United States Attorneys, to prioritize fentanyl trafficking cases. The Attorney General is also required to establish a process for these temporary reassignments within 180 days of the bill's enactment.