The Securing Partner Supply Chains Act mandates the Secretary of State to establish the Initiative on Foreign Investment Screening within 180 days of enactment. This Initiative aims to assist foreign countries in developing robust regulatory frameworks to screen foreign investments for national security risks, such as those related to critical infrastructure, sensitive technology, or supply chain vulnerabilities. The Secretary will coordinate with other U.S. government agencies and designate the Under Secretary for Economic Affairs or a designee to lead this effort. The Initiative's duties include providing technical assistance, training, and advisory services to partner countries, facilitating coordination among stakeholders, and supporting the development of screening mechanisms. It will also assess progress and conduct outreach to enhance global awareness of foreign investment risks. The Initiative is set to terminate after five years, and the Secretary must submit annual reports to Congress for three years detailing its activities, progress assessments, and emerging national security risks.