This bill establishes a new federal grant program aimed at combating the smuggling and trafficking of children and young women by amending the Trafficking Victims Protection Act of 2000. The program empowers the Attorney General and the Secretary of Health and Human Services , in consultation with the Secretary of State, to award grants to states, Indian tribes, local governments, and non-profit victims' service organizations. Its primary focus is twofold: to prevent the smuggling of children and young women aged 12 to 24 across U.S. borders, and to provide support for those in the same age group who have already been smuggled or are at risk of sex trafficking or severe forms of trafficking. To fund this initiative, the bill authorizes an appropriation of $50,000,000 to the Attorney General, which will remain available until expended for the grant program.