The "Hemp Safety Enforcement Act" amends the Agricultural Marketing Act of 1946, granting states and Indian tribes greater authority over the regulation of hemp and hemp-derived cannabinoid products. It establishes a new mechanism allowing states and tribes to **opt out** of federal hemp production regulations by submitting a notice to the Secretary of Agriculture. Upon opting out, states and tribes gain the ability to define "hemp" and "hemp-derived cannabinoid product" according to their own laws, with a specified federal exclusion still applying. A crucial condition for this self-regulation is the implementation of a **minimum age requirement** for the purchase of hemp-derived cannabinoid products. Furthermore, the bill explicitly ensures that opting out does not prohibit **interstate commerce** of these products to or from self-regulating jurisdictions, and no state or tribe can block such commerce. For trade between two self-regulating entities, products must comply with the laws of both jurisdictions.