This bill, titled the 21st Century Entrepreneurship Act, mandates the Small Business Administration (SBA) Administrator to develop and implement a comprehensive strategy for entrepreneurship and inventorship education. The core purpose is to address declining entrepreneurship rates and promote economic growth by targeting youth from disadvantaged communities. The Administrator will create a curriculum specifically designed for female students, minority students, English learners, children with disabilities, students from rural areas, and low-income students , who are often underrepresented in these fields. The strategy involves encouraging partnerships between the SBA's SCORE program volunteers and community learning centers to deliver this curriculum. SCORE volunteers are also encouraged to collaborate with other entrepreneurial development programs, such as small business development centers and women's business centers, to maximize impact. The bill requires the Administrator to submit biennial reports to Congress detailing program partnerships, student reach, and any barriers or improvements, and authorizes an appropriation of $2,500,000 annually for fiscal years 2026 through 2030 to carry out these provisions.