The "PREDICT Act" aims to establish a comprehensive national wastewater surveillance system for infectious disease detection and monitoring. It mandates the Secretary of Health and Human Services, acting through the CDC, to award grants, contracts, or cooperative agreements to eligible entities. These awards will support the establishment, maintenance, or improvement of activities related to detecting and monitoring infectious diseases through wastewater for public health emergency preparedness and response purposes. Eligible entities include State, Tribal, or local health departments, or partnerships involving these departments, which must submit detailed applications outlining their plans for surveillance and sustainability. Funds awarded under this Act are intended to enhance existing capabilities, conduct surveillance in high-risk rural areas or specific facilities, and implement evidence-based practices. The Secretary is also required to provide technical assistance to recipients and issue draft guidance within 180 days. This guidance will recommend assay use and establish standards for wastewater testing methods, metrics, and data reporting to a publicly available database and dashboard . Furthermore, the bill directs the Secretary to continue supporting research to improve the efficiency, sensitivity, and specificity of wastewater surveillance techniques and to develop evidence-based practices for estimating population-level data.