This legislation requires the Secretary of Health and Human Services to develop and issue comprehensive guidance within 12 months of its enactment. This guidance will focus on establishing best practices for the screening and treatment of congenital syphilis , specifically targeting State Medicaid programs, State Children's Health Insurance Programs (CHIPs), and various Indian health programs. The primary goal is to address the alarming rise in congenital syphilis cases by improving preventative and treatment measures. The guidance will cover several critical areas, including expanding access to syphilis screening for pregnant women and infants, educating both medical professionals and expectant mothers, and integrating telehealth services for improved care delivery. It will also emphasize strategies for increasing syphilis testing during the third trimester and at delivery, which are crucial for early detection and intervention. Furthermore, the bill mandates a report to Congress within two years, analyzing the implementation and effectiveness of these recommended best practices.