The "Defense Technology Hubs Act of 2025" mandates the Secretary of Defense to establish a new program aimed at enhancing national security and technological superiority. This program, known as the Defense Technology Hubs Program , will designate and support regional hubs focused on advancing defense technologies critical to national security. The Secretary will solicit applications from eligible consortia, which include universities, defense contractors, small businesses, and state/local governments, with a goal of designating at least 10 hubs within three years across diverse geographic regions. The primary objectives of these defense technology hubs are to accelerate the research, development, prototyping, and transition of emerging technologies like artificial intelligence, quantum technologies, and hypersonics into operational use. They will also foster partnerships among the Department of Defense, private industry, academic institutions, and local governments, while promoting workforce development and enhancing the resilience of the defense industrial base. Hubs must adhere to strict security and compliance requirements, including cybersecurity measures, export control regulations, and preventing participation by foreign entities of concern. The bill authorizes $375,000,000 for the program from fiscal years 2026 through 2030, with $75,000,000 specifically for grants to the hubs, where the federal share may not exceed 50% of total costs. The program will be administered by the Under Secretary of Defense for Research and Engineering, with provisions for waiving acquisition regulations for smaller projects to expedite development. The Secretary is also required to ensure the program complements existing defense innovation efforts and to conduct annual independent evaluations and submit reports to Congress on the program's effectiveness and performance.