The Ocean Regional Opportunity and Innovation Act of 2025 aims to establish Ocean Innovation Clusters across the United States to bolster the nation's "Blue Economy" and coastal communities. Within one year of enactment, the Secretary of Commerce, in consultation with other agencies, must designate at least seven eligible entities as these clusters. The primary goal is to strengthen the ocean economy through focused technological research and development, job training, and collaborative partnerships. Eligible entities for these clusters must be concentrated in a geographic region and comprise various organizations, including businesses, academic institutions, non-profits, and governmental entities, led by a non-profit. The Secretary will prioritize entities with a history of supporting Blue Economy growth and ensure geographic diversity, including specific regions like the Great Lakes and Gulf of Mexico. Considerations for designation include economic development potential, ability to serve diverse populations, and capacity for economic and climate resilience projects. These clusters will focus on several key areas, such as increasing pathways for new entrants into the Blue Economy, intellectual property management, and enhancing the sustainability of seafood supply chains. They will also promote advanced research, cross-sector science, technology development, and workforce training to create sustainable economic opportunities. Furthermore, the clusters will work with government agencies to clarify regulations and foster investable opportunities for small businesses. To further collaboration, the bill mandates the development or designation of at least one physical Ocean Innovation Center for Cross-Sector Collaboration within each cluster's region. Managed by the clusters, these centers will serve as hubs for partners, supporting entrepreneurs, creating collaborative workspaces, and strengthening industry relationships. They will also develop the next generation of Blue Economy workers through internships and training, including for underrepresented communities. The bill authorizes the Secretary of Commerce to award competitive grants to these Ocean Innovation Clusters for their operation and administration. These grants, with a term of two years and potential for renewal, aim to help clusters become self-sustaining, membership-based entities. Individual grants may not exceed $10,000,000, with $10,000,000 authorized annually for appropriations from fiscal years 2026 through 2030.