The MedShield Act of 2025 mandates the Secretary of Health and Human Services to implement the MedShield program , a comprehensive pandemic preparedness and response initiative. This program will leverage artificial intelligence and other advanced technologies to create a national medical shield, continuously monitoring threats and improving the delivery of medical solutions. Its core purpose is to safeguard public health by integrating innovations from public and private sectors, both domestically and internationally, to prevent future large-scale emergency responses. Under the MedShield program, the Secretary must develop a plan to integrate recommendations from the National Security Commission on Artificial Intelligence and consult with federal agencies and international partners for coordinated efforts. Key AI applications include developing a global pathogen surveillance system, accelerating vaccine identification and development, creating therapeutic treatments, and optimizing strategies for tracking and distribution. The bill authorizes significant appropriations, totaling $2 billion over five fiscal years, to fund these critical activities.