This bill establishes a biometrology laboratory program within the National Institute of Standards and Technology (NIST) to conduct measurement research for engineering biology, biomanufacturing, and biotechnology. Its core purposes are to enable innovation, enhance industrial competitiveness, and improve the accuracy and reliability of biological data and materials, while also supporting the safe and secure development of biological technologies. The program will support basic measurement science research, including understanding DNA-to-cell function and developing technologies for biomolecular components, alongside creating tools and technical standards for biological data. It specifically addresses biorisk, biosafety, and biosecurity concerns through the development of relevant standards and guidelines. NIST is tasked with convening stakeholders to develop technical roadmaps, providing access to user facilities, and supporting engineering biology foundries to improve measurement assurance. The Director will coordinate with other federal agencies, including the Manufacturing USA Program, and foster graduate and postgraduate training in biometrology. The program also requires establishing and updating common definitions for the bioeconomy, mandates reports on its implementation, and authorizes significant appropriations totaling over $300 million from fiscal years 2026 through 2030 to fund these critical initiatives.