This bill, titled the PFAS Cleanup Act, aims to mitigate the significant health and economic costs associated with perfluoroalkyl and polyfluoroalkyl substances (PFAS) pollution. It proposes amendments to the Internal Revenue Code of 1986 to introduce both a new excise tax on these chemicals and a credit for their removal from public water systems. Congressional findings highlight the substantial annual health costs and the high expense of removing PFAS from drinking water. The legislation establishes a new excise tax on PFAS, imposing a 45 percent levy on the sale price of these substances when sold by their manufacturer, producer, or importer. This tax applies to any man-made chemical with at least one fully fluorinated carbon atom that is manufactured, produced, or imported into the United States. The revenues generated are intended to partially address the financial burden of PFAS pollution. Furthermore, the bill creates a PFAS water remediation credit , allowing taxpayers to claim a credit equal to 25 percent of their qualified expenditures. These expenditures must be incurred by a public water system for the removal of PFAS when the substance is present at levels exceeding the Environmental Protection Agency's maximum contaminant level. This credit is designed to incentivize and support efforts by public water systems to ensure safer drinking water. Both the excise tax and the remediation credit are set to take effect for taxable years beginning after December 31, 2026.