This bill, known as the "Prevent the Misuse of Federal Law Enforcement Act," aims to significantly limit the independent operational authority of specific federal law enforcement agencies within state, tribal, and local jurisdictions. Its primary goal is to ensure that federal law enforcement actions, particularly those involving local personnel or responses to public demonstrations, are conducted with the explicit consent and coordination of the affected local governance. This measure seeks to reinforce principles of federalism and local control over law enforcement matters. The legislation amends the Controlled Substances Act to restrict Drug Enforcement Administration (DEA) agents' duties exclusively to investigations concerning drugs. It also modifies the powers of the U.S. Marshals Service , prohibiting them from deputizing state, local, tribal, or other federal law enforcement officers unless a formal request is made by the chief executive of the relevant jurisdiction. Furthermore, the bill addresses the law enforcement authority of the Secretary of Homeland Security concerning protest activities, stipulating that DHS may not designate additional employees for property protection during protests without a request from the appropriate chief executive, with an exception for Federal Protective Service employees.