This bill directs the Secretary of Health and Human Services to develop and publish updated, evidence-based clinical guidelines for effectively responding to nitazene overdoses , which are defined as overdoses involving nitazene or other ultra-potent synthetic opioids. These guidelines are intended to assist in addressing the growing problem of overdoses involving these substances by providing clear protocols for healthcare providers. The comprehensive guidelines must outline best practices for overdose response, including specific protocols for administering naloxone, and provide tailored guidance for emergency departments, hospitals, and rural and volunteer emergency medical services systems. The Secretary is required to publish these guidelines on the Department's public website within 180 days of the bill's enactment, making them publicly accessible to all relevant stakeholders. Furthermore, within one year, the Secretary must submit a detailed report to Congress that includes the finalized guidelines and describes how they will specifically assist in addressing the problem of nitazene overdoses, thereby ensuring accountability and informing future legislative actions.