This bill, titled the PrEP Assistance Program Act, directs the Secretary of Health and Human Services, through the Director of the Centers for Disease Control and Prevention, to establish a grant program within one year of enactment. This program will provide funding to eligible entities to establish or support pre-exposure prophylaxis (PrEP) programs, which are designed to offer PrEP medication and related services to individuals at risk of contracting HIV. Preference for these grants will be given to entities serving communities with disproportionately high rates of HIV incidence, such as rural areas, uninsured individuals, or specific demographic groups, or those demonstrating innovative service delivery models like pop-up clinics or peer-led interventions. Grants awarded under this program may not exceed $10,000,000 and must be used for expenses associated with PrEP programs, including clinic and laboratory fees, PrEP medication, various testing, adherence services, outreach, and mental health support. Importantly, individuals receiving services from these grant-funded programs cannot be required to pay for them. Grantees, excluding Indian Tribal governments, are generally required to contribute a 10% match, though this can be waived for certain entities like Federally qualified health centers. The bill also mandates annual reports to Congress for five years, detailing the impact of these grants, including disaggregated data by race, gender identity, age, and geographic location, and evaluating reductions in PrEP service disparities and overall HIV prevalence. To fund these initiatives, the bill authorizes an appropriation of $400,000,000 annually for fiscal years 2027 through 2031. Furthermore, the legislation requires the Secretary of Health and Human Services, through the Health Resources and Services Administration, to establish a separate program to reimburse healthcare providers for furnishing specified HIV prevention items and services to uninsured individuals. This program will also develop and distribute a "PrEP Pass" to ensure uninsured individuals can access these services from registered providers at no cost. Specified services include FDA-approved HIV prevention drugs, like PrEP, and associated diagnostic procedures recommended by CDC guidelines.