This bill establishes a program, led by the Secretary of Health and Human Services in consultation with other agencies, to significantly expand and enhance collaboration between the United States and Israel in the development and delivery of health care products and services. The initiative aims to foster joint efforts across various critical areas of medical innovation and public health. Key components of the program include promoting joint research projects in areas like medical device technology, pharmaceuticals, and digital health solutions, with a special focus on early-stage clinical trials. It also seeks to develop a framework for sharing health data for research purposes and support innovation in biological product manufacturing, including advanced techniques and workforce training. Furthermore, the bill emphasizes strengthening the innovation and start-up ecosystem by facilitating technology transfer and joint ventures between companies in both countries. It also addresses crucial aspects of regulatory harmonization and intellectual property protection, aiming for mutual recognition agreements and increased cooperation on regulatory standards. The program also focuses on sharing best practices for health care system strengthening, enhancing telemedicine infrastructure, and collaborating on digital health technologies and cybersecurity. Additionally, it includes initiatives for disease prevention, such as joint efforts to combat infectious diseases and develop vaccines. The Secretary may establish a joint United States-Israel Health Care Collaboration Center to leverage expertise, and the bill authorizes $8,000,000 annually for fiscal years 2026 through 2030 to fund these efforts.