This bill amends the Great Lakes Fishery Act of 1956 to empower the United States Section of the Great Lakes Fishery Commission to develop comprehensive efforts aimed at combating invasive species of mussels within the Great Lakes. These efforts are to be coordinated with various federal agencies, interstate compacts, and Tribal, State, and local governments. To support these initiatives, the bill mandates assistance from key federal entities, including the Secretary of the Interior, through the U.S. Fish and Wildlife Service and U.S. Geological Survey, and the Secretary of Commerce, through the National Oceanic and Atmospheric Administration. Furthermore, it authorizes a substantial appropriation of $500,000,000 for fiscal years 2026 through 2035 to fund these critical invasive mussel combat efforts. These funds are intended to supplement existing appropriations and will be made available to the Commission.