This bill, titled the "Defending International Security by Restricting Unacceptable Partnerships and Tactics Act" or "DISRUPT Act," requires the executive branch to develop a comprehensive, whole-of-government strategy. Its primary goal is to disrupt the growing cooperation among the People's Republic of China, the Russian Federation, the Islamic Republic of Iran, and the Democratic People's Republic of Korea, identified as foremost adversaries of the United States. This strategy aims to mitigate the significant risks posed by their alignment to U.S. national security. Congressional findings highlight that these adversaries are deepening cooperation across diplomatic, economic, and military spheres, reinforcing individual threats and posing new global challenges to U.S. strength. This includes significant defense cooperation through weapons transfers, dual-use technology sharing, and joint military activities, alongside coordination on disinformation and cyber operations. Their collaboration also seeks to circumvent U.S. and multilateral economic tools and expand influence in international institutions, allowing for faster military modernization and eroding the U.S. technological edge. The bill establishes a U.S. policy to disrupt the most dangerous aspects of this cooperation, constrain the adversaries' global footprint, and prepare for potential simultaneous challenges across multiple theaters by bolstering deterrence. To achieve this, it mandates the establishment of interagency task forces within the Departments of State, Defense, Treasury, and Commerce to evaluate and respond to adversary alignment. These task forces will comprise subject matter experts and representatives from core departmental functions, meeting quarterly to discuss findings. The Director of National Intelligence is required to submit a classified report detailing the current nature, extent, and trajectory of bilateral and multilateral cooperation among these adversaries, assessing the advantages gained and risks to U.S. and allied interests. This report must evaluate vulnerabilities within these relationships and the potential impact of U.S. efforts to separate adversaries. Additionally, the Secretaries of State and Defense must submit a classified report outlining a strategic approach to disrupt, frustrate, constrain, and prepare for adversary cooperation over a two-year period. The strategic approach report must detail methods to disrupt cooperation, including connectivity between defense industrial bases, and a timeline for engaging allies to combat adversary alignment. It also requires a plan to ensure the integrity of U.S. economic statecraft, assess sanctions enforcement, and bolster deterrence in the Indo-Pacific, Europe, and the Middle East. This includes increasing munitions stockpiles, facilitating co-production with allies, and updating Department of Defense war-planning tools to address evolving threats.