The bill, titled the "American Cooperation with Our Neighbors Act," directs the Secretary of State, in coordination with USAID, to develop a comprehensive strategy within 270 days to strengthen subnational cooperation between the United States and Mexico. This strategy is primarily aimed at enhancing law enforcement collaboration at local, state, and federal levels to curb fentanyl trafficking and other synthetic opioids. Key activities include bolstering technical assistance, carrying out professional development exchange programs, and enhancing data sharing, with a specific limitation on data sharing requiring congressional notification. Beyond law enforcement, the strategy also seeks to bolster subnational dialogue and capacity building among various stakeholders, including governments, civil society, and business leaders, integrating local community issues. It further emphasizes strengthening capacity building and providing resources for border towns and organizations that address community needs. Separately, the bill mandates the Secretary of State, in consultation with the Secretary of Treasury, to conduct a review of steps to expand financial access in Caribbean Community (CARICOM) member states, examining enforcement of international laws, reporting requirements for illicit finance, and potential expansion of diplomatic presence.