The "Financial Institution Regulatory Tailoring Enhancement Act" proposes to significantly increase the asset thresholds at which financial institutions become subject to specific federal regulations. This legislation aims to reduce regulatory burdens by raising the asset limit from $10 billion to $50 billion for several key financial statutes. Specifically, the bill amends the Consumer Financial Protection Act of 2010, the Bank Holding Company Act of 1956 (Volcker Rule), the Truth in Lending Act (qualified mortgages), and the Economic Growth, Regulatory Relief, and Consumer Protection Act (leverage and risk-based capital requirements). By increasing these thresholds, the bill would exempt financial institutions with assets between $10 billion and $50 billion from these particular supervisory, trading, mortgage, and capital requirements, thereby tailoring regulations based on institutional size.