The Humane Cosmetics Act of 2025 aims to significantly restrict animal testing for cosmetic products in the United States. Beginning one year after its enactment, the bill makes it unlawful to conduct or contract for cosmetic animal testing within the country. It also prohibits the sale, offer for sale, or transport in interstate commerce of any cosmetic product developed or manufactured using animal testing conducted after this effective date. The legislation generally prohibits the use of animal testing data conducted after the effective date to establish cosmetic safety under the Federal Food, Drug, and Cosmetic Act. However, it provides specific exemptions, such as testing conducted outside the U.S. to comply with foreign regulatory authority requirements , or testing for products regulated as drugs or medical devices. Another key exemption covers testing requested by the Secretary of Health and Human Services under strict conditions, including a finding that no non-animal alternative exists, evidence of adverse health effects, and public comment. The Act also exempts testing for non-cosmetic purposes required by regulatory authorities. To ensure national uniformity, the bill preempts state or local laws that are not identical to its prohibitions and exemptions regarding cosmetic animal testing or related data use. Violations of the Act can result in civil penalties of up to $10,000 per offense, with each animal involved or each day a violation continues constituting a separate offense.