This bill, titled the "Prison Rape Prevention Act of 2025," seeks to amend title 18 of the United States Code by establishing new rules for the Bureau of Prisons (BOP) regarding prisoner housing, transportation, and medical care. It mandates that the BOP must ensure prisoners are placed and transported exclusively among individuals of the same biological sex . The bill defines "biological sex" based on an individual's reproductive system, specifying criteria for male and female. Furthermore, the legislation prohibits the BOP from furnishing or paying for any gender-related medical treatment for prisoners. This includes a comprehensive list of surgical procedures, hormone therapies, and puberty blockers intended to address an individual's perception that their gender or sex does not align with their biological sex. However, it explicitly excludes medical treatments for diagnosed disorders of sex development, ambiguous biological sex characteristics, or complications arising from prior gender-related medical treatment.