This bill designates a 26-mile portion of Interstate 17 in Arizona, specifically between milepost 237 and 263, as the "Kayla Jean Mueller and Charles H. Keating IV Memorial Highway." This action aims to honor two Arizonans, Kayla Jean Mueller, a humanitarian aid worker, and Chief Petty Officer Charles H. Keating IV, a United States Navy SEAL. Both individuals tragically lost their lives while confronting the Islamic State of Iraq and Syria (ISIS), Mueller as a captive and Keating in combat, exemplifying American humanitarian and military ideals. The designation is explicitly honorary and is intended to complement, not replace or diminish, the existing "Arizona Veterans Highway" designation for Interstate 17. It clarifies that this change will not alter existing highway names, maps, or navigation systems, nor will it require additional federal funding. The bill directs the Secretary of Transportation to permit suitable honorary signage and memorialization at the Sunset Point Rest Area, and to include the designation in the Department's online repository.