Carbon Removal, Efficient Agencies, Technology Expertise Act of 2021 or the CREATE Act of 2021 This bill establishes the Committee on Large-Scale Carbon Management within the National Science and Technology Council to plan and oversee efforts to (1) remove carbon dioxide from the air, ocean, and land; and (2) store such carbon. The committee must develop a strategic plan for federal research, development, and demonstration of technological carbon dioxide removal and storage. In addition, the committee must establish working groups to carry out a Carbon Removal Initiative that pursues such research, development, and demonstration across several federal agencies.