Children's Safe Welcome Act of 2022 This bill imposes requirements related to the treatment of noncitizen children detained in immigration custody. For example, the bill (1) prohibits an accompanied noncitizen child from being separated from a parent or legal guardian while in immigration custody, except in certain situations; (2) requires each child in immigration custody to receive a legal orientation presentation and have access to legal counsel and child advocates; and (3) requires each unaccompanied noncitizen child in Department of Health and Human Services custody to be placed in the least restrictive setting that most approximates a family and in which any special needs may be met.