Clean Water Standards for PFAS 2.0 Act of 2022 This bill directs the Environmental Protection Agency to develop requirements to (1) limit the discharge of perfluoroalkyl and polyfluoroalkyl substances (PFAS) into certain waters of the United States, and (2) publish human health water quality criteria for PFAS. PFAS are man-made and may have adverse human health effects. A variety of products contain the compounds, such as nonstick cookware or weatherproof clothing.