Protecting Americans from Unnecessary Spread upon Entry from COVID-19 Act of 2022 or the PAUSE Act of 2022 This bill maintains immigration restrictions put in place under public health emergency authorities to prevent the introduction of COVID-19 from foreign countries. Specifically, the bill prohibits the Department of Health and Human Services from rescinding or reducing the stringency of the restrictions. It also prohibits the Department of Homeland Security from stopping or reducing enforcement of the restrictions. These prohibitions remain in effect until (1) federal and state COVID-19 emergency orders are lifted, and (2) the risk of introducing COVID-19 in or from Canada and Mexico is minimal.