Drone Act of 2022 This bill creates a federal statutory framework to criminalize various conduct involving the misuse of drones. Among its provisions, the bill generally prohibits the operation of a drone that poses an imminent safety hazard to vessels or motor vehicles; weaponization of a drone (e.g., attaching a firearm or explosive); and operation of a drone that interferes with a law enforcement, emergency response, or military operation or activity of the federal government or of a state, local, or tribal government.