Protecting Guides and Outfitters from Coronavirus Vaccine Mandates in the Great Outdoors Act This bill prohibits the denying of certain permit applications for activities on federal lands and waters for reasons based on the coronavirus vaccination status of applicants or their employees. Specifically, the Department of the Interior shall not deny based on vaccination status (1) a commercial use authorization to provide services to visitors to National Park System units, or (2) a special recreation permit for specialized recreation uses of federal recreational lands and waters.