National Science, Innovation, and Technology Strategy Act of 2021 This bill requires a national science and technology strategy and a technology review. The Office of Science and Technology Policy (OSTP) shall submit to Congress a comprehensive national science and technology strategy of the United States to meet national research and development objectives for the following four-year period. No later than one year after the enactment of this bill and every four years afterwards, the OSTP shall complete an interagency review of the science and technology enterprise of the United States.