Careful Resumption Under Improved Safety Enhancements Act or the CRUISE Act This bill requires various activities to mitigate the impact of COVID-19 on the operation of cruise ships. Specifically, the bill establishes a working group comprised of specified federal departments and industry stakeholders to develop recommendations for resuming cruise ship operations. In addition, the Centers for Disease Control and Prevention (CDC) must issue (within 30 days) separate recommendations on mitigating the introduction, transmission, and spread of COVID-19 onboard cruise ships and to communities onshore. The CDC must consult with the working group on these recommendations. Furthermore, the Department of Health and Human Services must revoke by July 4, 2021, its order issued on November 4, 2020, which restricts the operation of cruise ships in U.S. waters.