Safeguarding Human Rights in Arms Exports Act of 2021 or the SAFEGUARD Act of 2021 This bill establishes specified measures to prevent the sale, export, or transfer of defense articles or defense services to foreign countries for use in violation of international humanitarian law or internationally recognized human rights. These measures include (1) prohibiting arms sales to countries committing genocide or war crimes, (2) requiring a consideration of human rights practices and democratization in any foreign country to which an arms sale is contemplated, and (3) providing for congressional oversight of arms exports to foreign countries wherein certain human rights violations have occurred.