Endless Frontier Act This bill establishes a Directorate for Technology and Innovation in the National Science Foundation (NSF) and establishes various programs and activities. The goals of the directorate shall be, among other things, the strengthening of U.S. leadership in critical technologies through basic research in key technology focus areas, such as artificial intelligence, high performance computing, and advanced manufacturing, and the commercialization of those technologies to businesses in the United States. The bill gives the NSF the authority to provide for the widest practicable and appropriate dissemination of information within the United States concerning the NSF’s activities and the results of those activities. The Office of Science and Technology Policy shall annually develop a strategy for the federal government to improve national competitiveness in science, research, and innovation to support the national security strategy. The Department of Commerce shall (1) establish a supply chain resiliency and crisis response program to address supply chain gaps and vulnerabilities in critical industries, (2) designate regional technology hubs to facilitate activities that support regional economic development that diffuses innovation around the United States, and (3) award grants to facilitate development and implementation of comprehensive regional technology strategies. The bill extends through FY2026 the Manufacturing USA Program and expands such program to support innovation and growth in domestic manufacturing.