Assessing China's Presence and Influence in Latin America and the Caribbean Act of 2021 This bill requires the Department of State to report to Congress an assessment of China's efforts to expand its presence in Latin America and the Caribbean and how these efforts affect U.S. interests. The report shall include (1) a list identifying the countries that maintain the closest diplomatic, military, and economic relationships with China; (2) an analysis of which countries have received foreign assistance from China, including access to COVID-19 vaccines, and the conditions attached to that assistance; (3) a detailed description of sales or transfers of Chinese defense articles to countries in the region; and (4) an assessment of China's relationship with the Community of Latin American and Caribbean States.