Securing American Leadership in Science and Technology Act of 2021 This bill extends through FY2031 the Office of Science and Technology Policy (OSTP), the Office of Science of the Department of Energy, the Advanced Research Projects Agency-Energy, the National Institute of Standards and Technology (NIST), the National Oceanic and Atmospheric Administration (NOAA), and the National Science Foundation (NSF). The bill authorizes programs, projects, and activities, including those regarding (1) federal research security; (2) a National Supply Chain Database; (3) basic energy sciences research and advanced scientific computing research; (4) establishment and operation of Regional Energy Innovation Centers; (5) establishment of a carbon sequestration research initiative; (6) establishment of a NIST Foundation; (7) establishment of a technology transfer office in NOAA; (8) science, technology, engineering, and mathematics, including computer science (STEM) workforce development; and (9) establishment of an Energy Foundation. The OSTP shall submit a comprehensive national science and technology strategy, and complete a review of U.S. science and technology enterprise. The Office of Science shall continue to leverage U.S. participation in the Large Hadron Collider, prioritize international partnerships and investments in the Long-Baseline Neutrino Facility/Deep Underground Neutrino Experiment, and prioritize international collaboration that would provide U.S. researchers access to the most advanced accelerator facilities in the world. The Government Accountability Office shall evaluate NIST's Center for Neutron Research. The NSF shall contract the National Academy of Public Administration to study the organizational and management structure of the NSF.