COVID-19 Health Disparities Action Act of 2021 This bill requires the Centers for Disease Control and Prevention (CDC) to raise awareness about COVID-19 (i.e., coronavirus disease 2019) and promote vaccination among racial and ethnic minority groups and other populations that have experienced health disparities related to the disease. The CDC must conduct, subject to available funding, a public awareness campaign that targets those populations. The CDC must coordinate the campaign with the White House COVID-19 Health Equity Task Force and other federal, state, tribal, and local entities. The CDC must also award grants to health departments for similar COVID-19 awareness campaigns. Grant-funded campaigns must complement the CDC's campaign, as well as other efforts to inform the public about the disease. In addition, the Department of Health and Human Services must develop prototype materials for grantees to use in their campaigns.